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Cerebrinol cps 1×180 ks – Klasifikácia produktu: VDC90

Farmakológia a zdravotné tvrdenia k zloženiu

Na základe schválenia Európskej komisie č. 1924/2006 o výživových a zdravotných tvrdeniach, konkrétne zložky produktu Cerebrinol®:

  • prispievajú k adaptogénnej aktivite,
  • normalizujú činnosť nervového systému,
  • prispievajú k normálnej funkcii krvného systému,
  • zabezpečujú transport kyslíka,
  • prispievajú k normálnej činnosti cievnej sústavy
  • inhibitujú tvorbu tukového tkaniva. 

Certifikáty slúžia ako potvrdenie kvality a bezpečnosti produktu Cerebrinol®. Cerebrinol® (resp. jeho kvalita) bol (bola) preverená nezávislým akreditovaným laboratóriom, ktoré je držiteľom Osvedčenia o akreditácii SNAS č. 038/S-025.

Klinické štúdie synergického efektu kombinácie podobných zložiek ako v produkte Cerebrinol®

Can Combination Therapy of Conventional and Oriental Medicine Improve Poststroke Aphasia? Comparative, Observational, Pragmatic Study WooSang Jung, SeungWon Kwon, SeongUk Park, SangKwan Moon Evidence-Based Complementary and Alternative Medic.2012; 2012: 1.   
 

„The results of the present study suggest that the administration of language therapy in combination with oriental medicine therapy is effective for the treatment of post-stroke aphasia. Among patients with severe aphasia at onset, those in the COT (group that received language therapy with oriental medicine therapy) group exhibited better improvements than those in the OLT (group that received language therapy only) group, suggesting that the co-administration of oriental medicine therapy with language therapy revealed more effective tendency in the treatment of patients with severe aphasia.“

„The COT group exhibited a greater improvement than the OLT group in the total AQ score and most subsection scores. In particular, there were statistically significant differences in total AQ score and subsections such as spontaneous speech, content delivery, comprehension, auditory verbal comprehension, and command performance.“

Zhang X, Zhang XF, Wang L, et al. Analysis of Clinical Efficacy of Traditional Chinese Medicine in Recovery Stage of Stroke: A Systematic Review and Meta-Analysis. Cardiovasc Ther 2020; 2020:7172052

„These findings indicate that the combination of TCM treatment and routine treatment significantly improves the TER after routine treatment. These effects are mediated by the combined action of several mechanisms. It is likely that the TCMs combined with routine treatment also affect the blood lipid by regulating the contents of TC, TG, LDL, and HDL. The combination could decrease the expression of thrombus regulatory factor and coagulation effect by decreasing the level of hs-CRP, FIB, and HCY in serum. In the present study, the combination of TCM treatment could enhance the protection of neural function and improve the activity of daily life by decreasing the NIHSS scoring while increasing the BI scoring. The ACU or OTTCM combined with routine treatment displays a motor coordination ability by increasing the level of FMA scoring. TCMs combined with routine treatment can reduce the level of hemorheology by decreasing the level of WHV, WLV, PV, and HCT in serum. In this study, the combination of ACU treatment can improve the immune level of patients by reducing IgG, IgA, and IgM. In this study, the OTTCM combined with routine treatment can enhance the cognitive function and improve the spasmodic state by decreasing CSI and MRS and increasing the MOCA score. The ACU combined with routine treatment can improve swallowing function and activity ability by reducing SSA and increasing the level of VFSS and ADL. The ACU combined with routine treatment plays a neuroprotective role by increasing the levels of BFGF and VEGF. Paeoniae Radix Rubra, Angeticae Sinensis Radix, Astragali Radix, Puerariae Lobatae Radix, and Salviae Mihiorrhizae Radix et Rhizoma can effectively improve the clinical symptoms of stroke convalescent patients, promote the recovery of neurological function, and improve the ability of daily life. Acupuncture of Baihui (GV20), Sanyinjiao (SP6), Neiguan (PC6), Renzhong (GV26), Zusanli (ST36), and Taiyang (EX-HN5) can improve the clinical rehabilitation effect of patients and significantly improve the quality of life of patients. Moxibustion, needle knife, scraping, and other TCM therapy can significantly improve the indexes of stroke patients in the recovery period. However, our findings must be handled with care because of the small sample size and low quality of clinic trials cited. Other rigorous and large-scale RCTs are in need to confirm these results.“

Chen, X.; Chen, H.-S.; Peng, C.; Shen, J.-G., Active compounds and molecular targets of Chinese herbal medicine for neurogenesis in stroke treatment: Implication for cross talk between Traditional Chinese Medicine and Biomedical Sciences. World Journal of Traditional Chinese Medicine 2019, 5 (2), 104-115.

„In a TCM formula, the active compounds from different medicinal herbal components would yield much more complex interactions and network regulations than the single herb. The development of advanced chemical analytic technology and high throughput gene profile platforms provide a unique opportunity to explore the complex synergic effects of different active compounds in TCM formulas. In recent studies, many TCM formulas already revealed their promoting effects on promoting neurogenesis and recovering neurological deficits in the poststroke study. The progress of regeneration medicine and multiple advanced analytic technologies such as proteomics, metabolomics, and bioinformatics greatly facilitate us to explore the complex and magic world of TCM formulas. With the complex synergic effects and interactions, we will write a separate review article to discuss this important topic in the future.“

Shen J, Chen X, Chen X, Deng R. Targeting neurogenesis: A promising therapeutic strategy for post‑stroke treatment with Chinese herbal medicine. Integr Med Int 2014;1:5‑18.

„Overall, Chinese herbal medicine is an important resource for drug discovery and valuable therapeutic strategy to promote adult neurogenesis. Although the precise mechanisms and molecular targets are still unclear, current studies indeed bring novel insights into drug discovery and advancements in fighting post-stroke disability.“

Klinické štúdie jednotlivých zložiek produktu Cerebrinol®

Gong AGW, Wang HY, Dong TTX, Tsim KWK, Zheng YZ. Danggui Buxue Tang, a simple Chinese formula containing Astragali Radix and Angelicae Sinensis Radix, stimulates the expressions of neurotrophic factors in cultured SH-SY5Y cells. Chin Med 2017;12:24.

Závery štúdie:

„We revealed that DBT could up regulate the expres- sions of neurotrophic factors BDNF via MAPK/Erk signaling mechanism. Furthermore, we believed that MAPK/Erk signaling pathway could act as the fundamental role in regulating neuronal functions. Therefore, DBT shed light as health supplements or therapeutic treatments for neu- rodegenerative diseases, e.g. possible treatment of AD.“

Originálny názov:

C. H. Park, S. H. Choi, J. W. Koo et al., “Novel cognitive improving and neuroprotective activities of Polygala tenuifolia willdenow extract, BT-11,Journal of Neuroscience Research, vol. 70, no. 3, pp. 484–492, 2002.

Závery štúdie:

„We first reported that one or more components of BT-11 could penetrate the blood–brain barrier and improve cognitive impairment through elevating cholinergic neurotransmission by blocking ACh hydrolysis and could protect neurons against Glu, Aβ and CT, indicating that BT-11 and its components might be effective in treatment of Alzheimer’s disease. Further purification processes to isolate one or more active components from BT-11 and further analysis on its structure and effects should be carried out, however, to develop an effective neuroprotective and cognitive deficit-improving drug and to clarify its pharmacologic mechanisms.“

Adams JD, Wang R, Yang J, Lien EJ: Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions. Chin Med 2006;1:3.

Závery štúdie:

„S. miltiorrhiza is a very useful herb in the treatment of cardiovascular disorders. It has been extensively studied in clinical trials in China. Most of the clinical trials have some limitations. However, taken as a whole, the clinical trials present compelling evidence of the efficacy of S. miltiorrhiza in stroke, heart attack and other conditions. Further research is needed to understand all actions of S. miltiorrhiza, and all active compounds found in the plant, in treating cardiovascular diseases. Research is also needed to help us understand the pharmacological effects of other herbs added to S. miltiorrhiza.“

Y.-C. Wu and C.-L. Hsieh, “Pharmacological effects of Radix Angelica Sinensis (Danggui) on cerebral infarction,Chinese Medicine, vol. 6, article 32, 2011.

Závery štúdie:

„The effects of Danggui on cerebral infarction are through multiple pathways, including anti-arthrosclerosis, improving microcirculation, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects (Table ​(Table1).1). Danggui may be useful in treating the cerebral infarction type of stroke.“

Luo Z, Liu Y, Zhao Z, Yan X, Wang D, Liu Q. Effects of Astragalus injection and Salvia Miltiorrhiza injection on serum inflammatory markers in patients with stable coronary heart disease: a randomized controlled trial protocol. Trials 2020;21:267. [PMID: 32178701 DOI: 10.1186/s13063-020-4109-6]

Závery štúdie:

„In our previous studies, we found that the main components of astragalus, astragaloside IV, Salvia viltiorrhiza, and tanshinone IIA can effectively improve myocardial ischemic injury [13, 26]. Functionally, the mechanism of action of these drugs targeted cellular inflammation in myocardial ischemic injury and inhibited death. However, from a clinical point of view, it remains unclear whether individual astragalus and Salvia miltiorrhiza injections, or a combination of the two, result in significantly different antiinflammatory properties, during the treatment of CHD. This study will explore the effects of the astragalus injection, the Salvia miltiorrhiza injection, and their synergistic treatment on stable CHD from the antiinflammatory advantage, and provide the basis and basis for its clinical application.“

Yang QY, Lu S, Sun HR. Clinical effect of Astragalus granule of different dosages on quality of life in patients with chronic heart failure. Chin J Integr Med. 2011;17(2):146-9.

Závery štúdie:

„Results of the study indicated that AG at moderate dosage (9.0 g per day) could show a favorable effectiveness in improving heart contract function, but in improving QOL, it showed a dose- effect dependent tendency. Therefore, in clinical practice, the dosage of Radix Astragalus should be determined discriminatingly depending on the actual condition of patient and the aim of treatment.“

J. Ren, L. Fu, S.H. Nile, J. Zhang, G.Y. Kai Salvia miltiorrhiza in Treating cardiovascular diseases: A review on its pharmacological and clinical applications Frontiers in Pharmacology, 10 (2019), p. 753

Závery štúdie:

„Salvianolate, a major hydrophilic compound of Danshen, has a variety of cardiovascular protective effects, including antioxidative, anti-inflammatory, endothelial protection, myocardial protection, vasodilation, and anti-AS. Both TsIIA and salvianolate have cardioprotective effects with significant differences in their action of mechanism and effect (Wang et al., 2011). For example, tanshinone acts early after ischemic injury, mainly by inhibiting intracellular calcium and cell adhesion pathways, whereas salvianolic acid acts primarily by down-regulating apoptosis (Wang et al., 2011).“

„By reviewing clinical studies, it has been found that SM preparations have a good application in the treatment of CHD, hypertension, hyperlipidemia, PHD, and other diseases. However, there is a slight difference in Danshen preparation as STS injection has curative effect in the treatment of CHD, AP, PHD, and other diseases; The adjuvant medicine for the treatment of CVDs, compound Danshen injection can improve the symptoms of patients especially when combined with Western medicine; salvianolate injection has the function of promoting blood circulation and collaterals, and is often used for the treatment of cardiovascular and cerebrovascular diseases, such as AP and MI;“

Chen CC, Lee HC, Chang JH, et al. Chinese herb Astragalus membranaceus enhances recovery of hemorrhagic stroke: double-blind, placebo-controlled, randomized study. Evid Based Complement Alternat Med. 2012;2012:708452.

Závery štúdie:

„Therefore, we suggest that AM provides an advantage for acute hemorrhagic stroke patients, if treatment with AM is started within 24 hours of stroke onset. In particular, we found that AM therapy enhanced patients’ functional recovery for grooming, bathing, showering, dressing the lower body, and toileting. Additionally, the results show an excellent safety profile for treatment with AM; overall, the treatment was well-tolerated and none of the observed SAEs were considered drug related.“

„Therapy with AM has the effect of antioxidation and anti-inflammation, which indicates that AM can decrease edema and improve the patient’s prognosis [20, 21]. Our results showed that AM therapy improved functional outcomes at week 4 and at week 12 after hemorrhagic stroke onset, which may be due to AM’s properties of anti-inflammation and antioxidation, which would decrease brain edema.“

Liu CH, Tsai CH, et al. Effects of the traditional Chinese herb Astragalus membranaceus in patients with poststroke fatigue: A double-blind, randomized, controlled preliminary study. J Ethnopharmacol. 2016; 194:954-962.

Závery štúdie:

„AM can improve BFI scores; cognitive functioning, social functioning, and global QOL scores in the EORTC QLQ-C30. Our results suggest that physicians should pay close attention to the unmet medical needs of patients with PSF. AM is helpful for treating patients with PSF; however, additional studies with a larger sample and a longer period of investigation are required.“

Yang, W. T., Zheng, X. W., Chen, S., Shan, C. S., Xu, Q. Q., Zhu, J. Z., et al. (2017). Chinese herbal medicine for Alzheimer’s disease: Clinical evidence and possible mechanism of neurogenesis. Biochem. Pharmacol. 141, 143–155. doi: 10.1016/j.bcp.2017.07.002

Závery štúdie:

„The findings of the present systematic review support the view that CHM can be recommended for routine use for treatment of AD. Growing evidence indicates that CHMs may enhance adult hippocampal neurogenesis through the activation of multiple signaling pathways.“

Wang J, Hu J, Chen X, Lei X, Feng H, Wan F, Tan L: Traditional Chinese Medicine Monomers: Novel Strategy for Endogenous Neural Stem Cells Activation After Stroke. Front Cell Neurosci 2021, 15:628115.

„Currently, the TCMs research literature includes only a small number of high-quality studies, most of which are necessary studies, and a few clinical articles. However, TCMs could be effective tools to promote the neuroprotection, antiapoptotic differentiation, and proliferation of NSCs after stroke and their clinical safety has been validated by years of study. Different doses of TCMs can lead to opposing effects that may be caused by natural shortcomings such as water insolubility and low bioavailability. Nose-to-brain drug delivery (NBDD) vastly improves the efficacy of TCMs treatments by increasing their bioavailability and absorption rates and avoiding drug-induced gastrointestinal tract irritation. Additionally, biocompatible organic substance formulations and novel metal and oxide nanoparticles can change medication profiles and reduce the required dose and side effects.“